What’s the best treatment? Its effects might last longer if you have mild to moderate ED. Are you anxious, depressed or under stress? These small differences affect the way each medication works, such as how quickly it takes effect and wears off, and the possible side effects. What is erectile dysfunction? Work through relationship issues. They’re often the first line of treatment for trouble getting or keeping an erection, called erectile dysfunction ED.The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 . In many cases, erectile dysfunction is caused by something physical. Common causes include: Heart disease. Clogged blood vessels (atherosclerosis) High cholesterol. High . There are good treatments available for erectile dysfunction (ED). The medication Viagra (sildenafil) is the most well-known treatment. It’s been used safely for decades. .