It may be difficult to remain firm despite wanting to have sex. When choosing one, tell your doctor or other health care professional what your preferences are, such as cost, ease of use, how long the drug’s effects last and side effects. Severe liver disease. Those with a history of blood pressure or heart issues, hormonal imbalances, mental health issues, and diabetes should consult their doctor before trying PDE5 inhibitors. As with sildenafil, a high-fat meal or alcohol keep the body from absorbing it as quickly.Sildenafil (Viagra, Revatio) is a moderately priced drug used to treat erection problems in men. It is also used to treat pulmonary arterial hypertension, a serious heart and lung . The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 . Use GoodRx to look up prices and discount coupons at pharmacies in South Carolina and save up to 80% with our free coupons. Even if you have insurance or Medicare, .