Sildenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus HIV. And they do it despite warnings from the Food and Drug Administration, echoed by the pharmaceutical industry, about the risk of contaminated or counterfeit products. Also tell your doctor if you or any of your family members have or have ever had an eye disease such as retinitis pigmentosa an inherited eye condition that causes loss of vision or if you have ever had sudden severe vision loss, especially if you were told that the vision loss was caused by a blockage of blood flow to the nerves that help you see. So, if you need to take your medication every day, be sure to build in a sufficient margin for potential delays. In a study of healthy male volunteers, sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Population pharmacokinetic data from patients in clinical trials also indicated a reduction in sildenafil clearance when it was co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, or cimetidine [see Dosage and Administration 2.Still, if your doctor says it’s okay for you to use and you end up paying out-of-pocket, you can still get the generic for a lot less than Viagra. According to price-comparison site What Happened When I Took Viagra Recreationally. 1. Viagra was effective for much longer than four hours. Shutterstock. Viagra comes in three different sizes: 25mg, 50mg, or mg. In the past, I’ve found that 25mg always did the job just fine. However, my journey begins with a bottle of the mg tabs which I’ve chosen to cut into thirds. VIAGRA can cause your blood pressure to drop suddenly to an unsafe level if taken with certain other medicines. Do not take VIAGRA if you take any other medicines called “nitrates.” Nitrates are used to treat chest pain (angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke.