In , the Phase 2 clinical studies were initiated for males experiencing ED, then progressed to the Phase 3 trials that supported the drug’s FDA approval. The FDA has also approved tadalafil for treatment of both benign prostatic hypertrophy and erectile dysfunction where the two conditions co-exist. Soon, in , ICOS received a patent for compound IC structurally unlike sildenafil and vardenafil , and Phase 1 clinical trials began in If you’re not sure if you’re taking a nitrate, ask your doctor or pharmacist. Remember, when in doubt, always consult with a healthcare professional. Key facts It usually takes 30 to 60 minutes for tadalafil to work for erectile dysfunction. Cost-effective: Online platforms often offer competitive prices, discounts, and deals which can lead to significant savings.heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Common tadalafil side effects may include: headache; flushing (warmth, redness, or tingly feeling); nausea, upset stomach; stuffy nose; or. muscle pain, back pain, pain in your arms, legs, or back. This is not a complete list of side. About tadalafil Brand names: Cialis, Adcirca. About tadalafil. Tadalafil is a medicine used to treat erection problems (erectile dysfunction) and symptoms of an enlarged prostate (benign prostate enlargement). It’s also sometimes used to treat pulmonary hypertension (high blood pressure in the blood vessels that supply the lungs). Is the price for Cialis mg tablets more than for lower doses of the drug? Cialis comes in several different strengths, including: milligrams (mg) 5 mg; 10 mg; .