Tadalafil was approved in in the United States for the treatment of pulmonary arterial hypertension [28] and is under regulatory review in other regions for this condition. It works faster than Cialis Single, starts working in minutes and has a longer duration of action. One of the first Cialis ads aired at the Super Bowl. However, safety should always be the top priority. Brand-name versions of the drug approved for PAH include Adcirca. How Effective Is Cialis?Tadalafil is a generic drug that is widely known under the brand name Cialis. The estimated retail price of Tadalafil is $1, for 30, 20MG Tablet. When you use a free SingleCare Tadalafil coupon, you may be able to save significantly and lower your Tadalafil prescription cost to $ for 30, 20mg Tablet. $ (save %) local_offer_outlined. Avg retail price. $ medication_outlined. Availability. Available. See GoodRx coupons. warning. Are you looking for information on Adcirca (tadalafil) instead? What is Tadalafil (Cialis)? Drug Facts. Common Brands Cialis. Drug Class PDE-5 inhibitor. How Cialis Works. Tadalafil and other PDE5 inhibitors primarily work by inducing muscle relaxation. Tadalafil stops the breakdown of a chemical responsible for relaxing muscles. In ED and PAH, the drug targets muscle cells in blood vessels. When the blood vessel muscle cells relax, this expands the vessel and increases blood flow; this .