Tadalafil may not be safe for people with certain medical conditions, including people who have had a stroke , have coronary heart disease or retinitis pigmentosa an eye disease. While each PDE5 inhibitor differs slightly, they’re very similar in treating erectile dysfunction. It may be difficult to remain firm despite wanting to have sex. Make sure to get an estimate of when you can expect your prescription in the mail. Comparison with actions of other PDE5 inhibitors[ edit ] Sildenafil and vardenafil inhibit PDE6, an enzyme found in the eye, more than tadalafil.The normal dosage of Cialis for occasional use in treating ED is 10 mg taken before sexual activity. If you have side effects with the mg dose, your doctor may prescribe a 5-mg dose. If the The drug comes in low-dose versions that can be taken daily. This means you can have sex at any time, rather than needing to take a pill from time to time as needed like other ED brands. The starting dose for daily-use Cialis is milligrams (mg). If that doesn’t work, you can increase your daily dose up to 5 mg.  · But on average, its effects start to lessen 2 to 3 hours after you take a dose. The typical dose for once-daily Cialis for ED is milligrams (mg) to 5 mg. When used as needed for ED, the usual.

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