If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. Also, in rare cases, vardenafil use may cause priapism, a very painful emergency condition that can cause impotence if left untreated. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections. If you have had a stroke or a heart attack. Cardiovascular Discuss with patients the potential cardiac risk of sexual activity for patients with preexisting cardiovascular risk factors.Uses. Vardenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, vardenafil works by increasing blood flow to the. Nifedipine: Vardenafil 20 mg (film-coated tablets), when co-administered with slow-release nifedipine 30 mg or 60 mg once daily, did not affect the relative AUC or C max of nifedipine, a drug that is metabolized via CYP3A4. Nifedipine did not alter the plasma levels of vardenafil when taken in combination. Vardenafil hydrochloride orally. · Description and Brand Names Drug information provided by: Merative, Micromedex ® US Brand Name Levitra Staxyn Descriptions Vardenafil is used to treat men with erectile dysfunction (sexual impotence). It belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors.